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Roxette Roxette Category:Roxette Category:Roxette compilation albums Roxette RoxetteThe transcription factor nuclear factor-kappaB is required for the expression of the interleukin-6 gene. Interleukin-6 (IL-6) is a cytokine that induces a number of immune responses and is critical for the development of acute inflammatory disease. The transcriptional regulation of the human IL-6 gene has been examined using the human T-cell line, Jurkat E6.1. These cells have previously been shown to spontaneously secrete IL-6, making them an ideal system in which to study IL-6 transcription. The IL-6 gene is under the control of both positive and negative cis-acting elements. Transfection studies using IL-6-luc reporter gene constructs have identified a 100 bp region that is required for IL-6 promoter activity. Mutation of the putative Sp1 sites did not abolish promoter activity, but the Sp1 site was critical for the action of T-cell nuclear factor-kappaB (NF-kappaB). The putative Sp1 sites were mutated by deletion of the Sp1 motif, addition of a point mutation to block transcription factor binding and deletion of the motif, leaving a nonconsensus consensus sequence. NF-kappaB binding was dependent on the presence of the proximal Sp1 motif. These data demonstrate that the IL-6 promoter is regulated by NF-kappaB, suggesting that this transcription factor may be critical for the expression of this cytokine in human lymphoid cells.The Warriors found some humor in the situation and even fired back at the Minnesota Timberwolves on Twitter. The new deal is set to pay Curry $5 million this season, $4 million next season, $5 million in 2021-22, $5 million in 2022-23 and $6 million in 2023-24. Curry, in his fourth season in the Bay Area, will make $22.9 million this season and $24.1 million in 2021-22, $25.1 million in 2022-23 and $27.2 million in 2023-24. The Warriors and Curry are also saving on luxury-taxes next season, which is why Curry is guaranteed $5 million in this season, $4 million in next season, $4 million in 2021-22, $5 million in 2022-23 and $

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